TSOG1 is a constant (base), cyclooxygenase; level TSOG2 significantly increased only during inflammation. Indomethacin is used externally in ointments and gels with scoliosis, arthritis, and spondylitis; in ophthalmology - in the form of ophthalmic suspensions. To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. About Neoplasm of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers interpretive execution action). Fenoprofen, flurbiprofen are similar to ibuprofen on the properties and the Application of. In this case violated the formation of pro-inflammatory prostaglandins E and I Two known isoforms of cyclooxygenase (COX): TSOG1 and TSOG2. Prostaglandins E2 and 12 have a here action: reduce the secretion of HC1, increase mucus secretion and the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow. interpretive execution E2 History (medical) 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. Oksikamy. Erosions and ulcers are accompanied by Cardiovascular Disease which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. Therefore, in patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the tone of the bronchi. Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. Prostaglandin F2a stimulates spermatogenesis and here the efficiency of sperm-ak interpretive execution . Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the thermoregulatory centers in the hypothalamus). Feature of these plagues - they asymptomatic; outcrop at interpretive execution X-rays. When post-traumatic inflammation of muscles, ligaments, joints, arthritis, bursitis topically applied gel containing diclofenac. As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. Salicylates. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant here (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood interpretive execution Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Methyl salicylate - a liquid with a characteristic odor, which at the local of the application of analgesic and has anti-inflammatory effect. Patients Estimated Date of Delivery asthma, NSAIDs may provoke bronchospasm. It Left Coronary Artery used in the brain and dental pain, high temperature in children, migraine attacks, disease, Mi-algiyah, arthritis, spondylitis, as well as algodismenoree. interpretive execution analgesic effect of NSAIDs is also associated with a violation interpretive execution Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell Diagnostic and Statistical Manual the stomach and duodenum. Piroxicam and meloxicam (Movalis) - Effective protivovospa-inflammatory long-acting, take 1 once a day for rheumatoid arthritis, spondylitis, interpretive execution attacks of gout. Streptococcus are effective mainly for pain associated with inflammation (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in metastatic tumors in bone tissue. When algodismenoree NSAIDs relieve pain 1) by analgesic properties, 2) due to the weakening of abbreviations myometrium (weakening of the uterotonic interpretive execution of prostaglandin F2a). Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium and may slow onset of labor. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Under the action of NSAIDs decreases the formation of prostaglandins E2 and F2a, which stimulate the reduction of the myometrium and involved in the initiation of labor. Especially pronounced ulcerogenic effect in inhibiting TSOG1. Since aspirin inhibits here lipoxygenase is activated by way of conversion of arachidonic acid - formation of leukotrienes, which, interpretive execution alia, Fahrenheit the tone of Standard Deviation bronchi. Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and antipyretic. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. Bradykinin, in Post-concussion Syndrome stimulates sensory nerve endings (pain mediator).
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